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au:Kershenobich, David

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Ulloa-Aguirre, Alfredo

; Kershenobich, David

Revista de investigación clínica

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Out 2021, Volume 73 Nº 5 Páginas 265 - 265

Resumo: En | Texto: En | PDF: En

https://doi.org/10.24875/ric.21000423

The National Institute of Medical Sciences and Nutrition Salvador Zubirán: A Brief Journey Through its History
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Kershenobich-Stalnikowitz, David

Revista de investigación clínica

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Out 2021, Volume 73 Nº 5 Páginas 266 - 269

Resumo: En | Texto: En | PDF: En

https://doi.org/10.24875/ric.21000387 2 downloads

Factors Associated with COVID-19 and Asymptomatic Carriage in Healthcare Workers of a COVID-19 Hospital
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Ochoa-Hein, Eric

; Rajme-López, Sandra

; Leal-Morán, Patricia E.

; Vargas-Fernández, Abril T.

; González-Lara, María F.

; Alberto-Hernández, María F.

; Bustos-Román, Daniel E.

; Valverde-Ramos, Lirio N.

; Ramos-Cervantes, Pilar

; Cervantes-Villar, Luz E.

; Ibarra-González, Violeta

; Ponce-de-León, Alfredo

; Galindo-Fraga, Arturo

; Kershenobich-Stalnikowitz, David

; Sifuentes-Osornio, José

Revista de investigación clínica

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Abr 2021, Volume 73 Nº 2 Páginas 65 - 71

Resumo: En | Texto: En | PDF: En

ABSTRACT Background: Risk factors for coronavirus disease (COVID-19) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) asymptomatic carriage (AC) in healthcare workers (HCWs) have been scarcely characterized. Objective: The objective of the study was to study factors associated with COVID-19 and AC in HCWs of a COVID-19 academic medical center. Methods: This is a case-control study. Cases were either symptomatic or asymptomatic HCWs with a positive SARS-CoV-2 polymerase chain reaction (PCR) test result between March 16 and May 21 of 2020. Adjusted odds ratios (aOR) were calculated by means of multivariable logistic regression. In addition, each subject was followed for 14 days to inform outcomes. Results: One hundred thirty of 249 (52.2%) symptomatic HCWs had COVID-19; 10 were hospitalized but none died. Of 987 asymptomatic HCWs, 37 (3.7%) were AC; 6 of the remaining 950 asymptomatic HCWs with a negative PCR test result were found to be presymptomatic COVID-19 cases the following 14 days. Nurses were more frequently present in the COVID-19 group (51.5% vs. 37.0%), but multivariable analysis rendered non-significant results. After adjustment for age, comorbidities, and working place, factors found to be associated with AC were: working in wards as a nurse (aOR = 9.19, 95% confidence interval [CI] = 1.05-80.22, p = 0.045), kitchen personnel (aOR = 4.09, 95% CI = 1.55-10.83, p = 0.005), and being a physician (aOR = 0.12, 95% CI = 0.03-0.54, p = 0.006). Conclusions: HCW category was the predominant factor associated with AC of SARS-CoV-2 in this study.

https://doi.org/10.24875/ric.20000592 259 downloads

Submuestra para el análisis de enfermedades crónicas con biomarcadores, Encuesta Nacional de Salud y Nutrición 2016
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Hernández-Alcaraz, César

; Shamah-Levy, Teresa

; Romero-Martínez, Martín

; Sepúlveda-Amor, Jaime

; Aguilar-Salinas, Carlos A

; Rivera-Dommarco, Juan

; Kershenobich-Stalnikowitz, David

; Hernández-Ávila, Mauricio

; Barquera, Simón

Salud Pública de México

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Out 2020, Volume 62 Nº 5 Páginas 504 - 510

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Objetivo: Describir la submuestra de adultos para el análisis de biomarcadores de enfermedades crónicas, así como los tamaños de muestra (n) y la representatividad de las mismas en la Encuesta Nacional de Salud y Nutrición 2016. Material y métodos: Se calculó una submuestra con representatividad nacional para la obtención de sangre, suero y orina en adultos. Se comparó la prevalencia de variables de interés para las submuestras. Resultados: Las n obtenidas de suero y orina fueron de 4 000 y 3 782 adultos con al menos un valor en algún marcador bioquímico sérico y marcadores de orina, respectivamente. Esta n varió con el agrupamiento de marcadores y selección por horas de ayuno. No se observaron diferencias en la distribución de las variables de interés entre las muestras de hogar, sangre y orina. Conclusión: Los datos ponderados de las submuestras de marcadores en orina, suero y sangre son comparables con la muestra total de adultos de la encuesta. Los datos de las submuestras permitirán monitorear la distribución de enfermedades crónicas en México, incluidas las alteraciones en función hepática, renal, y consumo de sodio.

Abstract Objective: To describe the adult subsample for the analysis of biomarkers of chronic diseases, as well as the sample sizes (n) and representativity of the Encuesta Nacional de Salud y Nutrición (Ensanut) 2016. Materials and methods: An adult subsample with national representativity was calculated to obtain blood, serum and urine samples. The prevalence of variables of interest was compared for each subsample. Results: The n for at least one serum biomarker and urine samples were 4 000 and 3 782, respectively. The n varied depending on the grouping of biomarkers and fasting time selection. No differences were observed in the distribution of variables between the whole sample, urine and blood biomarkers samples. Conclusion: The weighted subsamples of urine, serum and blood biomarkers are comparable to the weighted sample of adults in the survey. The data of the subsample will allow to monitor the distribution of chronic diseases in Mexico, including altered function of liver and kidney, and sodium intake.

https://doi.org/10.21149/11306 13 downloads

Clinical and Epidemiological Characteristics of Patients Diagnosed with COVID-19 in a Tertiary Care Center in Mexico City: A Prospective Cohort Study
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Ortiz-Brizuela, Edgar

; Villanueva-Reza, Marco

; González-Lara, María F.

; Tamez-Torres, Karla M.

; Román-Montes, Carla M.

; Díaz-Mejía, Bruno A.

; Pérez-García, Esteban

; Olivas-Martínez, Antonio

; Rajme-López, Sandra

; Martinez-Guerra, Bernardo A.

; León-Cividanes, Nereyda A. de

; Fernández-García, Oscar A.

; Guerrero-Torres, Lorena

; Torres-González, Lorena

; Carrera-Patiño, Fabián A.

; Corral-Herrera, Ever A.

; Hernández-Alemón, Aldo N.

; Tovar-Vargas, Maria de los Ángeles

; Serrano-Pinto, Yamile G.

; Espejo-Ortiz, Cristian E.

; Morales-Ortega, María de la L.

; Lozano-Cruz, Óscar A.

; Cárdenas-Fragoso, José L.

; Vidal-Mayo, José de J.

; Hernández-Gilsoul, Thierry

; Rivero-Sigarroa, Eduardo

; Domínguez-Cherit, Guillermo

; Cervantes-Villar, Luz E.

; Ramos-Cervantes, Maria del P.

; Ibarra-González, Violeta

; Calva-Mercado, Juan J.

; Sierra-Madero, Juan G.

; López-Íñiguez, Álvaro

; Ochoa-Hein, Eric

; Crabtree-Ramírez, Brenda E.

; Galindo-Fraga, Arturo

; Guerrero-Almeida, María de L.

; Ruiz-Palacios, Guillermo M.

; Gulías-Herrero, Alfonso

; Sifuentes-Osornio, José

; Kershenobich-Stalnikowitz, David

; Ponce-de-León, Alfredo

Revista de investigación clínica

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Jun 2020, Volume 72 Nº 3 Páginas 165 - 177

Resumo: En | Texto: En | PDF: En

ABSTRACT Background: Regional information regarding the characteristics of patients with coronavirus disease (COVID)-19 is needed for a better understanding of the pandemic. Objective: The objective of the study to describe the clinical features of COVID-19 patients diagnosed in a tertiary-care center in Mexico City and to assess differences according to the treatment setting (ambulatory vs. hospital) and to the need of intensive care (IC). Methods: We conducted a prospective cohort, including consecutive patients with COVID-19 from February 26, 2020 to April 11, 2020. Results: We identified 309 patients (140 inpatients and 169 outpatients). The median age was 43 years (interquartile range, 33-54), 59.2% men, and 18.6% healthcare workers (12.3% from our center). The median body mass index (BMI) was 29.00 kg/m2 and 39.6% had obesity. Compared to outpatients, inpatients were older, had comorbidities, cough, and dyspnea more frequently. Twenty-nine (20.7%) inpatients required treatment in the IC unit (ICU). History of diabetes (type 1 or 2) and abdominal pain were more common in ICU patients compared to non-ICU patients. ICU patients had higher BMIs, higher respiratory rates, and lower room-air capillary oxygen saturations. ICU patients showed a more severe inflammatory response as assessed by white blood cell count, neutrophil and platelet count, C-reactive protein, ferritin, procalcitonin, and albumin levels. By the end of the study period, 65 inpatients had been discharged because of improvement, 70 continued hospitalized, and five had died. Conclusions: Patients with comorbidities, either middle-age obese or elderly complaining of fever, cough, or dyspnea, were more likely to be admitted. At admission, patients with diabetes, high BMI, and clinical or laboratory findings consistent with a severe inflammatory state were more likely to require IC.

https://doi.org/10.24875/ric.20000211 533 downloads

Dilemmas of a Physician in Times of COVID-19
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Kershenobich, David

Revista de investigación clínica

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Jun 2020, Volume 72 Nº 3 Páginas 125 - 126

Resumo: En | Texto: En | PDF: En

https://doi.org/10.24875/ric.20000218 68 downloads

Correlation of hepatic fibrosis assessed by Metavir score and digital morphometry in a murine model
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Alemán-García, Nathalie

; Sánchez-Pérez, Celia

; Pérez-García, Adolfo

; Durán-Padilla, Marco A.

; Kershenobich, David

; Hernández-Ruíz, Joselín

Revista médica del Hospital General de México

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Mar 2020, Volume 83 Nº 1 Páginas 13 - 19

Resumo: En | Texto: En | PDF: En

Background: Animal models for hepatic fibrosis are currently used for clinical studies, and research works aimed to the progression and regression of the disease. In these, fibrosis is evaluated using histopathological assessment with high variability inter- and intra-observers. Digital morphometry in the space color LAB could reduce this variability; however, its correlation degree with the histopathological assessment is unknown. Objective: The objective of the study was to analyze the correlation between digital morphometry and the histopathological assessment of hepatic fibrosis in images of biopsies of a murine model. Materials and methods: We performed a descriptive, experimental, longitudinal, prospective, analytical, and correlational study. Fibrosis was induced by intraperitoneal injection of carbon tetrachloride in 16 Wistar male rats. We did a postmortem hepatectomy and took histological specimens stained by Masson trichrome, obtaining ten randomly selected images at ×10 in each liver. We quantified the fibrosis percentage (FP) by digital morphometry and compared it to the Metavir score given by three independent evaluators. FP was analyzed by a ANOVA test and Spearman Rho test. Results: The evaluated images had 70% concordance of the three evaluators. The analysis of the FP revealed fibrosis evaluation groups with statistical differences. The FP had a very high correlation with the histopathological diagnosis (p = 0.0001, r = 0-9). The ranges obtained from FP for each phase of fibrosis were: 0.4% for F0, 0.44-1.14% for F1, 1.52-2.74% for F2, 3.1-3.8% for F3y, and 5.12-6.12% for F4. Conclusions: The morphometric quantification had a high correlation with the histopathological evaluation of images of histological sections of liver biopsies of the murine model of fibrosis. The quantification of the FP by digital morphometry will be useful to increase the accuracy in the evaluation of liver fibrosis.

https://doi.org/10.24875/hgmx.m20000034 47 downloads

Acciones prioritarias para un programa nacional de detección, tratamiento y seguimiento de pacientes con hepatitis C
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Wolpert-Barraza,, Enrique

; Muñoz-Hernández, Onofre

; Kershenobich-Stalnikowitz, David

Salud Pública de México

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Abr 2019, Volume 61 Nº 2 Páginas 212 - 216

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract: In the Mexican health scenario, the hepatitis C virus epidemic is present, along with its comorbidities and premature mortality. Acting immediately will allow its containment in short term with the proper implementation of the current available tools for prevention, diagnosis and highly effective pharmacological therapies. The Coalition for the study of hepatitis C in Mexico has developed a position paper that takes advantage of these containment measures and presents the development of a National program for the detection, timely treatment and follow-up of patients with hepatitis C.

Resumen: En el escenario de la salud mexicana, la epidemia por virus de la hepatitis C se encuentra presente junto con sus comorbilidades y mortalidad prematura. Actuar de manera inmediata permitirá una contención de la misma en el corto plazo dada la existencia de herramientas de prevención, diagnóstico y terapias farmacológicas altamente eficaces. La Coalición para el estudio de la hepatitis C en México ha desarrollado una postura donde aprovecha esas medidas de contención y presenta el desarrollo de un programa nacional para la detección, tratamiento oportuno y seguimiento de pacientes con hepatitis C.

https://doi.org/10.21149/10166 829 downloads

Acciones prioritarias para un programa nacional de detección, tratamiento y seguimiento de pacientes con hepatitis C
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Wolpert-Barraza, Enrique

; Muñoz-Hernández, Onofre

; Kershenobich-Stalnikowitz, David

Salud Pública de México

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Abr 2019, Volume 61 Nº 2 Páginas 212 - 216

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

https://doi.org/10.21149/10166

10.

Presentación
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Kershenobich, David

; Shamah-Levy, Teresa

Salud Pública de México

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Jun 2018, Volume 60 Nº 3 Páginas 222 - 223

Resumo: Es | Texto: Es | PDF: Es

https://doi.org/10.21149/9622 9 downloads

11.

Presentación
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Kershenobich, David

; Shamah-Levy, Teresa

Salud Pública de México

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Jun 2018, Volume 60 Nº 3 Páginas 222 - 223

Resumo: Es | Texto: Es | PDF: Es

https://doi.org/10.21149/9622 191 downloads

12.

Lactancia materna en México
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Kershenobich.*, David

Salud Pública de México

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Jun 2017, Volume 59 Nº 3 Páginas 346 - 347

Resumo: Es | Texto: Es | PDF: Es

https://doi.org/10.21149/8800 17400 downloads

13.

Lactancia materna en México
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Kershenobich, David

Salud Pública de México

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Jun 2017, Volume 59 Nº 3 Páginas 346 - 347

Resumo: Es | Texto: Es | PDF: Es

https://doi.org/10.21149/8800 489 downloads

14.

Los criterios de elegibilidad actuales del Seguro Popular para recibir tratamiento para el virus de la hepatitis C
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Moctezuma-Velázquez, Carlos

; Sánchez-Ávila, Juan Francisco

; García-Juárez, Ignacio

; Uscanga-Domínguez, Luis Federico

; Kershenobich-Stalnikowitz, David

Salud Pública de México

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Dez 2016, Volume 58 Nº 6 Páginas 591 - 592

Resumo: Es | Texto: Es | PDF: Es

https://doi.org/10.21149/spm.v58i6.7865 739 downloads

15.

Los criterios de elegibilidad actuales del Seguro Popular para recibir tratamiento para el virus de la hepatitis C
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Moctezuma-Velázquez, Carlos

; Sánchez-Ávila, Juan Francisco

; García-Juárez, Ignacio

; Uscanga-Domínguez, Luis Federico

; Kershenobich-Stalnikowitz, David

Salud Pública de México

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Dez 2016, Volume 58 Nº 6 Páginas 591 - 592

Resumo: Es | Texto: Es | PDF: Es

https://doi.org/10.21149/spm.v58i6.7865 283 downloads

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